Cholestyramine: An Effective, Twice-Daily Dosage Regimen

  1. CONRAD B. BLUM, M.D.;
  2. RICHARD J. HAVLIK, M.D.; and
  3. JOEL MORGANROTH, M.D.
  1. Bethesda, Maryland

    Abstract

    Nine patients with familial hypercholesterolemia (type II hyperlipoproteinemia) and two normal volunteers were studied to ascertain the effectiveness of cholestyramine in lowering plasma cholesterol when a twice-a-day dosage regimen was compared with the same total dosage administered four times a day. The study showed that in these subjects the two regimens were equally effective. The ability to administer cholestyramine twice daily in working adults and school children should greatly enhance adherence to this agent.

    Article and Author Information

    • ▸ From The Molecular Disease and Lipid Metabolism Branches, National Heart and Lung Institute, National Institutes of Health; Bethesda, Maryland.

    • ▸ Requests for reprints should be addressed to R. J. Havlik, M.D.; Molecular Disease and Lipid Metabolism Branches, National Heart and Lung Institute; Building 31, Room 4A18; Bethesda, MD 20014.

      • Received January 26, 1976.
      • Accepted May 24, 1976.
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    1. Ann Intern Med September 1, 1976 vol. 85 no. 3 287-289
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