RSS Feeds
Dilantin®, Agranulocytosis, and Phagocytic Marrow Histocytes
- MIN-FU TSAN, M.D., PH.D.;
- DAVID J. MEHLMAN, M.D.;
- ROBERT S. GREEN, M.D.; and
- WILLIAM R. BELL, M.D., F.A.C.P.
Excerpt
Agranulocytosis associated with Dilantin®* (diphenylhydantoin) therapy has been reported in five cases (1-5) and only two had bone-marrow aspiration during the acute stage (3-4). We report the occurrence of agranulocytosis with marked phagocytosis of myeloid precursors by marrow histiocytes in a patient taking Dilantin.
A 15-year-old black girl was admitted to the Johns Hopkins Hospital after having fever and chills for 3 days. She had complained of intermittent headache, episodic abdominal pain, and momentary loss of consciousness in the 5 months before admission, but no abnormality was found on examination and electroencephalography. Because of increasingly frequent attacks, treatment with Dilantin
Article and Author Information
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↵* Parke, Davis & Co., Detroit, Michigan.
