1-Alphahydroxycholecalciferol in Chronic Renal Failure

Studies of the Effect of Oral Doses

  1. M. W. J. DAVIE, M.B.;
  2. T. M. CHALMERS, M.D.;
  3. J. O. HUNTER, M.D.;
  4. B. PELC, Ph.D.; and
  5. E. KODICEK, M.D., Ph.D., F.R.S.
  1. Cambridge,
    England

    Abstract

    Four patients with advanced chronic renal failure and osteodystrophy were treated with 1-alphahydroxycholecalciferol, a synthetic vitamin D analogue, in a daily oral dose of 1.5 to 2.0 µg, for periods up to 1 year. They showed increased calcium absorption, positive calcium and phosphorus balances, moderate increases in serum calcium levels, marked reductions in serum alkaline phosphatase levels, a decrease in serum immunoreactive parathyroid hormone levels, and radiologic and histologic improvement in bone disease. One patient with proximal myopathy showed improvement in muscular strength. 1-Alphahydroxycholecalciferol appears to be effective therapy for renal osteodystrophy.

    Article and Author Information

    • ▸From Addenbrooke's Hospital, the Dunn Nutritional Laboratory and the Strangeways Research Laboratory, Cambridge, England.

    • ▸Requests for reprints should be addressed to T. M. Chalmers, M.D., Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, England.

      • Received November 21, 1975.
      • Accepted December 9, 1975.
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    This Article

    1. Ann Intern Med March 1, 1976 vol. 84 no. 3 281-285
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