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Deficiency of the Second Component of Complement (C2) with Chronic Vasculitis
- PETER FRIEND, M.D.;
- JOHN E. REPINE, M.D.;
- YOUNGKI KIM, M.D.;
- C. C. CLAWSON, M.D.; and
- ALFRED F. MICHAEL, M.D.
Abstract
A patient had complete deficiency of the second component of complement associated with chronic vasculitis and increased susceptibility to infection. We discuss here results of the complement profile, histocompatibility typing, and studies of the functional properties of patient plasma or serum in chemotaxis and opsonization in relation to the disease entity and host susceptibility to infection.
Article and Author Information
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▸From the University of Minnesota Medical School, Minneapolis, Minnesota.
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Aided in part by grants from The Basil O'Connor Starter Research fund of the National Foundation-March of Dimes, Minnesota Heart Association, Minnesota Arthritis Foundation, Minnesota Medical Foundation CA-11996, and the Midwest Kidney Foundation. Dr. Repine is a recipient of a Young Pulmonary Investigator Award (NIH-HL) and a Minnesota Heart Fellowship.
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▸Requests for reprints should be addressed to Peter Friend, M.D., Department of Medicine, Box 194 Mayo, University of Minnesota, Minneapolis, MN 55455.
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- Received May 27, 1975.
- Accepted September 18, 1975.
