Disulfiram Hepatotoxicity

Excerpt

Keeffe and Smith (1) recently reported a case of hepatotoxicity caused by disulfiram. Despite wide use of disulfiram for the treatment of alcoholism, hepatotoxic reactions had not previously been noted. Hepatotoxic reactions may be extremely rare; alternatively, drug-related hepatic disease may have been overlooked because of the high prevalance of alcoholic liver disease in the population treated with disulfiram. We describe a patient who developed severe hepatic dysfunction after two separate exposures to disulfiram.

The patient is a 49-year-old black man with a history of chronic alcoholism. He has been in good health and had been hospitalized only once for