Juvenile Polyposis and Gastrointestinal Carcinoma

A Study of a Kindred

  1. THOMAS J. STEMPER, M.D.;
  2. THOMAS H. KENT, M.D.; and
  3. ROBERT W. SUMMERS, M.D., F.A.C.P.
  1. Iowa City, Iowa

    Abstract

    A kindred contained at least 10 members with single or multiple juvenile polyps of the stomach and large intestine. Several additional polyps had both adenomatous and juvenile features. Eleven members of the kindred have had gastrointestinal carcinoma of the stomach, duodenum, pancreas, or proximal colon. The pattern of inheritance in this kindred suggests either a single or two closely linked autosomal dominant determinants for gastrointestinal carcinoma and polyposis. Management of this kindred is complicated due to the occurrence of gastrointestinal carcinoma without polyposis.

    Article and Author Information

    • ▸From the Departments of Internal Medicine and Pathology, University and Veterans Administration Hospitals, University of Iowa College of Medicine, Iowa City, Iowa.

    • ▸Requests for reprints should be addressed to Robert W. Summers, Department of Internal Medicine, Division of Gastroenterology, University Hospitals, Iowa City, IA 52240.

      • Received March 31, 1975.
      • Accepted July 23, 1975.
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    This Article

    1. Ann Intern Med November 1, 1975 vol. 83 no. 5 639-646
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