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Profiles of Antinuclear Antibodies in Systemic Rheumatic Diseases
Abstract
The prevalence of different antinuclear antibodies was examined in systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, progressive systemic sclerosis, dermatomyositis, discoid lupus erythematosus, and mixed connective tissue disease. Antibody to Sm antigen (a nuclear acidic protein) was found almost exclusively in serums of patients with systemic lupus erythematosus, suggesting that this antibody might be a "marker" antibody for this disease. However, antibodies to native DNA and to nuclear ribonucleoprotein were found in a variety of systemic rheumatic diseases. In systemic lupus erythematosus, antibody to native DNA was present in high titer but in other rheumatic diseases in low titer. Antibody to nuclear ribonucleoprotein occurred in certain other systemic rheumatic diseases besides the mixed connective tissue disease syndrome. These studies showed that there were distinct profiles of antinuclear antibodies in certain systemic rheumatic diseases, characterized by the presence or absence of certain antibodies and by differences in their mean titers.
Article and Author Information
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▸From the Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California.
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This paper is publication No. 921 from the Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California.
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Grant support: National Institutes of Health grant AM12198. Dr. Notman is a postdoctoral trainee under National Institutes of Health grant AI00214.
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▸Requests for reprints should be addressed to E. M. Tan, M.D., Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, CA 92037.
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- Received January 20, 1975.
- Accepted June 23, 1975.
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