Rash, Weakness, and Acetaminophen

Excerpt

Acetaminophen is generally known as an analgesic-antipyretic agent with few adverse effects. Most reports of adverse reactions involve liver damage, thrombocytopenia, and other hematologic reactions, while very few include rash and weakness. This letter reports a case of a generalized rash and body weakness attributed to acetaminophen.

A 64-year-old white man had a 12-year history of hypertension that had been treated with reserpine but now was being treated with hydrochlorothiazide. Four and a half years before admission the patient had a myocardial infarction, was hospitalized for 2 weeks, rested at home for 3 weeks, and was treated with warfarin for