LDH-Binding Immunoglobulins

Excerpt

To the editor: The paper by Dr. Thomas and associates in the October 1974 issue (Ann Intern Med 81:434-439, 1974) prompts me to report the case of a 64-year-old man with oxyphenisatin-induced lupoid hepatitis.

Total lactate dehydrogenase (LDH) activity in serum was 653 Wróblewski units per litre. The serum LDH isoenzyme pattern showed only a single component that was in the LDH-4 position. A hemolysate of washed erythrocyte cells from this patient showed a normal LDH isoenzyme pattern. On gel filtration through a Sephadex G-200 column, all of the LDH activities of this patient's serum were eluted between 7S and