Penicillin G Therapy in Renal Failure

Excerpt

To the editor: The article by Bryan and Stone (Ann Intern Med 82:189-195, 1975) is a welcome example of attempts by clinicians to apply pharmacokinetic concepts to drug use during renal failure for enhancement of efficacy with reduction in toxicity. Earlier guidelines for the use of drugs in renal impairment, as in this paper, have tended to advocate the administration of conventional or moderately reduced doses of drugs at long intervals (1). Less attention has been paid to the effects of giving small doses of the drug at conventional intervals to maintain more constant serum levels of the drug.

The