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Pseudomonas aeruginosa Infections: Persisting Problems and Current Research to Find New Therapies
- HERBERT Y. REYNOLDS, M.D.;
- ARTHUR S. LEVINE, M.D.;
- ROBERT E. WOOD, Ph.D., M.D.;
- CHARLES H. ZIERDT, Ph.D.;
- DAVID C. DALE, M.D.; and
- JAMES E. PENNINGTON, M.D.
Abstract
Despite the availability of specific antibiotics, Pseudomonas aeruginosa bacteria still cause troublesome infections in patients with a variety of illnesses: extensive thermal injury, leukopenia from antineoplastic chemotherapy and other forms of immunosuppressive treatment, chronic pulmonary disease such as cystic fibrosis, or intravenous narcotic use. The use of antibiotics has improved the prognosis of pseudomonas infections considerably. However, patients with marginal or defective host immunity may need more extensive therapy to master the infection. By evaluating additional modalities of treatment such as granulocyte replacement, improved usage of antibiotics, and active (prophylaxis) or passive antibody administration, the optimal combination may be found.
Article and Author Information
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▸An edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda, Maryland, 28 March 1974, by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health, Education, and Welfare.
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▸Requests for reprints should be addressed to Herbert Y. Reynolds, M.D., Bldg. 10, Room 11B-13, National Institutes of Health, Bethesda, MD 20014.
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- Received March 21, 1975.
- Accepted March 25, 1975.
