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Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency
- G. DOUGLAS CAMPBELL, JR., B.A.;
- MARTIN H. STEINBERG, M.D., F.A.C.P.; and
- JOHN D. BOWER, M.D., F.A.C.P.
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Mr. Campbell and Drs. Steinberg and Bower:
Divisions of Hematology and Nephrology
Department of Medicine
University of Mississippi School of Medicine
Jackson, Mississippi 39216
Dr. Steinberg:
Special Hematology Laboratory
Veterans Administration Hospital
Jackson, Mississippi 39216
Excerpt
Though the origins of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are rooted in human antiquity, the presence of drug-induced hemolysis in individuals subsequently felt to have G-6-PD deficiency was first reported in 1926 and the biochemical lesion responsible for this phenomenon elucidated in 1956 (1). In the United States, hemolysis induced by infection or drugs is the most common clinical manifestation of G-6-PD deficiency (2).
Ascorbic acid (vitamin C), an essential vitamin, is commonly used in pharmacologic doses for the prevention of the common cold and to promote the healing of wounds. We report here an individual with G-6-PD deficiency who
This 100-word excerpt has been provided in the absence of an abstract.
