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Familial Neutrophil Chemotaxis Defect, Recurrent Bacterial Infections, Mucocutaneous Candidiasis, and Hyperimmunoglobulinemia E
- ROBERT E. VAN SCOY, M.D.;
- HARRY R. HILL, M.D.;
- ROY E. RITTS, Jr., M.D., F.A.C.P.; and
- PAUL G. QUIE, M.D.
Abstract
A 20-year-old woman and her infant daughter had recurrent bacterial infections and chronic mucocutaneous candidiasis and were found to have extreme hyperimmunoglobulinemia E, defective neutrophil chemotaxis, and diminished lymphocyte responses to Candida antigen. Studies of members of the mother's family showed mild increases of IgE and mildly depressed chemotactic activity of neutrophils in a brother, the father, and the paternal grandfather. The recurrent bacterial infections in these two patients can be explained by the defective neutrophil chemotaxis. It is not known whether the mucocutaneous candidiasis is related to the neutrophil chemotaxis with the lymphocyte defect being secondary to the Candida infection or, alternatively, the Candida infection being secondary to the lymphocyte defect. Furthermore, the family data suggest a familial pattern of hyperimmunoglobulinemia E and defective neutrophil motility.
Article and Author Information
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▸From the Division of Infectious Diseases and Internal Medicine and the Department of Microbiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, and the Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.
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Grant support: in part by U.S. Public Health Service grants AI 08821 and AI 06931, the Department of Pediatrics training grant HD 00053-13, and a grant from the Twin Cities Diabetes Association, Minneapolis, Minnesota.
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▸Requests for reprints should be addressed to Dr. Robert E. Van Scoy, Mayo Clinic, Rochester, MN 55901.
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- Received October 11, 1974.
- Accepted February 2, 1975.
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