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Tumor Angiogenesis: A Possible Control Point in Tumor Growth
Abstract
The growth of solid tumors has an avascular phase and vascular phase. These discrete phases each have unique properties; a diffusible tumor angiogenesis factor seems to be responsible for initiating the vascular phase; and when the avascular phase is prolonged, solid tumors in a variety of experimental models fail to grow beyond a few millimetres. This perspective of the manner by which solid tumors grow has become a guide for further experiments to elucidate the nature of tumor angiogenesis factor, to determine whether tumor neovascularization can be inhibited, and to find out whether the neovascularization that sometimes accompanies wound healing, inflammation, or delayed hypersensitivity operates through a different mechanism than tumor angiogenesis.
Article and Author Information
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▸From the Department of Surgery, Harvard Medical School and The Children's Hospital Medical Center, Boston, Massachusetts.
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Grant support: grant CA14019, National Cancer Institute, U. S. Public Health Service; and grant DT-2A, American Cancer Society.
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▸Requests for reprints should be addressed to Judah Folkman, M.D., The Children's Hospital Medical Center, 300 Longwood Ave., Boston, MA 02115.
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- Received July 3, 1974.
- Accepted July 29, 1974.
