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Granulocytes in Human Disease
- MARTIN J. CLINE, M.D.;
- CHARLES G. CRADDOCK, M.D., F.A.C.P.;
- ROBERT P. GALE, M.D.;
- DAVID W. GOLDE, M.D., F.A.C.P.; and
- ROBERT I. LEHRER, M.D.
Abstract
The neutrophilic granulocyte develops from a committed hemopoietic stem cell under hormonal and microenvironmental influences. By the promyelocyte stage it begins to develop its arsenal of lysosomal enzymes and soon thereafter develops its phagocytic capabilities. These two features—phagocytosis and lysosomal enzymes—are critical in supporting the neutrophil's defense function and play a key role in many inflammatory reactions. Abnormalities of granulocyte production, morphogenesis, or function occur in a wide variety of human disorders. The discussions that follow review the physiology and function of the normal cell and the aberrations that occur in granulocytic diseases.
Article and Author Information
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*Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California.
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▸An edited transcription of the Clinical Case Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles, California.
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▸Requests for reprints should be addressed to Martin J. Cline, M.D., Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles, CA 90024.
