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Hepatocellular Carcinoma and Partial Deficiency of Alpha-1 Antitrypsin (MZ)
- WILLIAM RAWLINGS, Jr., M.D., M.S. Hyg.;
- JOEL MOSS, M.D., Ph.D.;
- HARRY S. COOPER, M.D.; and
- STANLEY R. HAMILTON, M.D.
Abstract
Z allele alpha-1 antitrypsin deficiency has been associated with hepatic fibrosis and cirrhosis. Previous case reports have suggested an association between the homozygous (ZZ) state and hepatocellular carcinoma. Two patients are presented who had cryptogenic liver disease and alpha-1 antitrypsin deficiency of the MZ phenotype. At postmortem both were found to have hepatocellular carcinoma. The rarity of both the Z allele and hepatocellular carcinoma may suggest an association between heterozygous Z allele alpha-1 antitrypsin deficiency and this malignancy.
Article and Author Information
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▸From the Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, Maryland.
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▸Requests for reprints should be addressed to Wm. Rawlings, Jr., M.D., The Johns Hopkins Hospital, Baltimore, MD 21205.
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- Received May 21, 1974.
- Accepted August 13, 1974.
