Glomerular Sclerosis and IgG Deposits

Excerpt

To the editor: The article by Matalon and co-workers in the April 1974 issue of the Annals entitled, "Glomerular Sclerosis in Adults with Nephrotic Syndrome" presents findings not generally reported in such cases. The authors describe continuous linear deposits of IgG at the glomerular basement membrane in all patients. In the discussion section they raise the possibility that the deposits might represent physical entrapment of IgG but promptly dismiss the idea. I would be more willing to dismiss the entrapment theory if antialbumin conjugates had failed to bind to the glomerular basement membrane. Without this latter control, the failure to