Repeated Immunization: Possible Adverse Effects
Reevaluation of Human Subjects at 25 Years
- CHARLES S. WHITE III, M.D.;
- WILLIAM H. ADLER, M.D.; and
- VIRGINIA G. McGANN, Ph.D.
Abstract
A group of intensively immunized men, who had been subjected to detailed medical evaluations in 1956 and in 1962, was reexamined in 1971 and compared with a carefully matched control group. Clinical and laboratory studies were done to detect adverse effects induced by repeated parenteral inoculation with a variety of vaccines and toxoids. No clinical sequels attributable to long-term immunization were identified. Only one laboratory abnormality described in previous studies, elevated serum hexosamine, was observed. Few other abnormalities were detected in the immunized group; mean values were depressed for serum
Article and Author Information
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▸From the U S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
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▸Requests for reprints should be addressed to Charles S. White, III, M.D., Division of Hematology, George Washington University Medical Center, 2150 Pennsylvania Ave., Washington, DC 20037.
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- Received April 5, 1974.
- Accepted July 15, 1974.
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