Repeated Immunization: Possible Adverse Effects

Reevaluation of Human Subjects at 25 Years

  1. CHARLES S. WHITE III, M.D.;
  2. WILLIAM H. ADLER, M.D.; and
  3. VIRGINIA G. McGANN, Ph.D.
  1. Fort Detrick, Frederick, Maryland

    Abstract

    A group of intensively immunized men, who had been subjected to detailed medical evaluations in 1956 and in 1962, was reexamined in 1971 and compared with a carefully matched control group. Clinical and laboratory studies were done to detect adverse effects induced by repeated parenteral inoculation with a variety of vaccines and toxoids. No clinical sequels attributable to long-term immunization were identified. Only one laboratory abnormality described in previous studies, elevated serum hexosamine, was observed. Few other abnormalities were detected in the immunized group; mean values were depressed for serum

    Article and Author Information

    • ▸From the U S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.

    • ▸Requests for reprints should be addressed to Charles S. White, III, M.D., Division of Hematology, George Washington University Medical Center, 2150 Pennsylvania Ave., Washington, DC 20037.

      • Received April 5, 1974.
      • Accepted July 15, 1974.
    « Previous | Next Article »Table of Contents

    This Article

    1. Ann Intern Med November 1, 1974 vol. 81 no. 5 594-600
    1. » Abstract
    2. Full Text (PDF)
    3. A correction has been published

    Rapid Responses

    1. Submit a response
    2. No responses published

    Current Issue

    1. November 17, 2009, 151 (10)
    1. Alert me to current issues