RSS Feeds
The Pathogenesis of Hypercholesterolemia
Abstract
Elevation of serum cholesterol level is caused by decreased output and increased input. Increased input, as manifested by increased synthesis, seems to be the more common mechanism. Many of the acknowledged risk factors in the development of coronary artery disease are characterized by increased cholesterol formation. It is proposed that the most frequent biologic risk factor that underlies a large number of the many other seemingly separate effectors is the excessive flux of fat to the liver.
Article and Author Information
-
▸From the Palo Alto Medical Clinic, Palo Alto, California.
-
▸Requests for reprints should be addressed to Walter M. Bortz, M.D., Palo Alto Medical Clinic, 300 Homer Ave., Palo Alto, CA 94301.
-
- Received November 26, 1973.
- Accepted February 25, 1974.
