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Skin Immunofluorescence Studies on Lupus Erythematosus and Other Antinuclear-Antibody-Positive Diseases
- JAY GROSSMAN, M.D.;
- MARY LOU CALLERAME, M.D.; and
- JOHN J. CONDEMI, M.D., F.A.C.P.
Abstract
The deposition of gamma globulins and complement at the dermal-epidermal (D-E) junction of normal-appearing skin was found by direct immunofluorescence in 54% of patients with systemic lupus erythematosus and in only one patient with procainamide-induced lupus. No patients with rheumatoid arthritis or other antinuclear-antibody-positive connective tissue diseases showed this deposition. The D-E junction staining was found only in patients with clinically active systemic lupus erythematosus, but it could not be correlated with specific organ system involvement.
Article and Author Information
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▸From the Allergy-Immunology Service, Department of Medicine, University of Rochester Medical Center, Rochester, New York; and Department of Medicine, William Beaumont Army Medical Center, El Paso, Texas.
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Grant support: training grant AI-00028, and service research grant RR-00044, U.S. Public Health Service, Washington, D.C.
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▸Requests for reprints should be addressed to Jay Grossman, M.D., Allergy-Immunology Service, William Beaumont Army Medical Center, El Paso, TX 79920.
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- Received August 2, 1973.
- Accepted January 4, 1974.
