The Granular Type II Pneumonocyte and Lung Antioxidant Defense
Excerpt
Two cell types predominate in mammalian alveolar epithelium: [1] Type I cells (membranous pneumonocytes), which have a small, nucleated cell body with attenuated peripheral cytoplasm containing a relative paucity of intracytoplasmic organelles, and which cover most of the alveolar surface; and [2] Type II cells (granular pneumonocytes), which are nearly cuboidal with abundant cytoplasmic organelles, including moderate amounts of endoplasmic reticulum, ribosomes, and lamellar inclusions, and which cover areas of the alveolar surface not lined by type I cells. The lamellar inclusions of the type II cells represent sites of synthesis of pulmonary surfactant, the phospholipid-rich substance primarily responsible for
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
ACKNOWLEDGMENTS: The author thanks Drs. M. G. Mustafa, A. J. DeLucia, W. S. Tyler, D. L. Dungworth, C. K. Chow, and A. L. Tappel of the University of California at Davis Pulmonary Disease Research Group; and Drs. M. J. Evans and R. J. Stephens of the Stanford Research Institute for collaboration; and Dr. P. D. Hoeprich for his editorial suggestions.
Article and Author Information
-
Grant support: U.S. Public Health Service-National Institutes of Health grant 5PO1, ES00628, and 2 PO6 RR1069; and a grant from the Council for Tobacco Research-U.S.A.
-
- Received July 16, 1973.
- Accepted November 8, 1973.
Most Read
