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Glucose-6-Phosphate Dehydrogenase Deficiency in Sickle-Cell Anemia
A Study in Adults
Abstract
There is evidence that the prevalence of G-6-PD deficiency is greater than would be expected in individuals with sickle-cell anemia, which suggests a survival advantage for these patients. We have studied 45 individuals with sickle-cell anemia, with methods for detecting G-6-PD deficiency in the presence of reticulocytosis, and we have found its prevalence to be similar to that of control subjects. The patients were mostly adults with mild sickle-cell disease. The differences between our findings and those reported previously may be partly owing to the nature of the populations studied. Our findings do not provide evidence that G-6-PD deficiency in adults with sickle-cell anemia gives them any advantage in survival.
Article and Author Information
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▸From the Hematology Research Laboratory, Jackson Veterans Administration Center; and the Department of Medicine, Division of Hematology, University of Mississippi School of Medicine; Jackson, Mississippi.
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Grant support: partly supported by Veterans Administration research funds.
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▸Requests for reprints should be addressed to Martin H. Steinberg, M.D., Associate Chief of Staff for Research, Veterans Administration Center, Jackson, MS 39216.
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- Received July 19, 1973.
- Accepted October 2, 1973.
