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Immunogenicity of Inactivated Influenza Virus Vaccine in Chronic Renal Failure
- M. COLIN JORDAN, M.D.;
- WYATT E. ROUSSEAU, M.D.;
- GARY E. TEGTMEIER, PH.D.;
- GARY R. NOBLE, M.D.;
- ROBERT G. MUTH, M.D., F.A.C.P.; and
- TOM D. Y. CHIN, M.D.
Abstract
Patients with chronic renal failure are candidates for immunization against influenza. Impairment of cell-mediated immunity has been documented in patients with uremia, but studies of serum antibody responsiveness against various antigens show conflicting results. No data are available on serum antibody responses of patients with chronic renal failure who were given influenza vaccine. We compare the serum hemagglutination-inhibition antibody responses to inactivated, bivalent influenza virus vaccine of 22 renal-dialysis patients and 28 normal control subjects. No significant differences were found in the temporal, geometric mean titer responses or the frequency of fourfold or greater rises in antibody titer, with either influenza A or influenza B antigen. Since uremic patients on hemodialysis respond adequately to influenza vaccine, annual vaccination is recommended.
Article and Author Information
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▸From the Virus Disease Section, Kansas City Laboratories, Ecological Investigations Program, Center for Disease Control, Health Services and Mental Health Administration, U.S. Department of Health, Education, and Welfare, Kansas City, Kansas; and the Artificial Kidney and Nephrology Center, Research Hospital, Kansas City, Missouri.
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▸Requests for reprints should be addressed to Gary R. Noble, M.D., Respiratory Virology Section, Bureau of Laboratories, Center for Disease Control, Atlanta, GA 30333.
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- Received April 30, 1973.
- Accepted August 16, 1973.
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