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A Balanced Reciprocal Chromosomal Translocation in Three Generations
Identification by Giemsa Staining
Abstract
Three generations in a kindred have been studied for identification of a chromosome structural rearrangement not previously described in man. Staining by G-banding methods identified the rearrangement as a truly reciprocal, balanced translocation involving chromosome pairs 1 and 2. This study shows the sensitivity of new staining methods in confirming a reciprocal exchange of genetic information and in identifying break-point regions on each chromosome.
Article and Author Information
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▸From the Division of Medical Genetics, Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, California.
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▸Requests for reprints should be addressed to O. W. Jones, M.D., Division of Medical Genetics, Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92037.
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- Received March 29, 1973.
- Accepted May 31, 1973.
