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Calcium Pyrophosphate Dihydrate Crystal Deposition in Neuropathic Joints
Four Cases of Polyarticular Involvement
- SERGIO JACOBELLI, M.D.;
- DANIEL J. McCARTY, M.D., F.A.C.P.;
- DONALD C. SILCOX, M.D.; and
- JAY C. MALL, M.D.
Abstract
Three men and one woman with late, latent syphilis and neurotrophic knee joints are reported here. One had calcium pyrophosphate dihydrate crystal deposition in several joints, without abnormal neurological changes; the other three showed some of the neurological lesions of tabes dorsalis and this joint deposition. We postulate a pathogenetic synergism of the two conditions. Because neuroarthropathy should be excluded before proceeding with endoprosthetic joint replacement, it is important to establish the cause of severe peripheral joint degeneration with precision, by careful neurologic, radiologic, and laboratory examination.
Article and Author Information
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▸From the Section of Arthritis and Metabolism, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois.
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▸Requests for reprints should be addressed to Daniel J. McCarty, M.D., 950 E. 9th St., Chicago, IL 60637.
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- Received April 25, 1973.
- Accepted June 1, 1973.
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