Gaucher's Disease: Neurologic Disorder in Adult Siblings

  1. J. D. MILLER, M.D.;
  2. ROBERT McCLUER, Ph.D.; and
  3. JULIAN N. KANFER, Ph.D.
  1. Cleveland, Ohio, and Waltham, Massachusetts

    Abstract

    Two adult siblings with biochemically and histologically documented Gaucher's disease as well as a similar diffuse neurologic disorder are presented. The family history suggests that a third, deceased sibling also had a similar neurologic disorder associated with Gaucher's disease. There have been no previous reports of a similar neurologic disorder in adult-type Gaucher's disease.

    Article and Author Information

    • ▸From the Department of Internal Medicine, Cleveland Metropolitan General Hospital, Cleveland, Ohio; and the Department of Biochemical Research, Eunice Kennedy Shriver Center for Mental Retardation, Inc., at the Walter E. Fernald State School, Waltham, Massachusetts.

    • Grant support: HD05515 and NS8994, U.S. Public Health Service; and 724, National Multiple Sclerosis Society.

    • ▸Requests for reprints should be addressed to J. D. Miller, M.D., Clover Fork Clinic, Box 187, Evarts, KY 40828.

      • Received November 15, 1972.
      • Accepted February 22, 1973.
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    This Article

    1. Ann Intern Med June 1, 1973 vol. 78 no. 6 883-887
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