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Hypouricemia due to Renal Uricosuria
A Case Study
Abstract
A 57-year-old healthy man had a plasma uric acid level of 0.2 to 0.58 mg/100 ml. The 24-hour urinary urate excretion was normal, at 797 mg. Urate clearance was 48% higher than endogenous creatinine clearance. Urinary xanthine and hypoxanthine levels were at the upper limit of normal. There was no evidence of phosphaturia, glucosuria, or aminoaciduria. A 10-year-old son of his maternal cousin had a plasma urate level of 1.2 mg/100 ml and a urate clearance equal to 42% of endogenous creatinine clearance. The findings in this subject could be accounted for by an isolated defect of tubular urate reabsorption or a tubular mechanism for urate secretion.
Article and Author Information
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▸From the Departments of Medicine and Biochemistry, American University of Beirut, Beirut, Lebanon; and the Department of Pediatrics, Northwestern University Medical School, The Children's Memorial Hospital, Chicago, Illinois.
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▸Requests for reprints should be addressed to A. K. Khachadurian, M.D., Clinical Research Center, The Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614.
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- Received November 13, 1972.
- Accepted January 4, 1973.
