RSS Feeds
Effect of Induced Fever on Sulfobromophthalein Kinetics in Man
- TERRENCE F. BLASCHKE, M.D.;
- RONALD J. ELIN, M.D., Ph.D.;
- PAUL D. BERK, M.D., F.A.C.P.;
- CHULL S. SONG, M.D., Ph.D., F.A.C.P.; and
- SHELDON M. WOLFF, M.D., F.A.C.P.
Abstract
The effect of fever induced by endotoxin or etiocholanolone on sulfobromophthalein (BSP) kinetics was examined in 20 healthy volunteers by analyzing the plasma disappearance curves obtained after a single injection of 5.0 mg/kg body weight of BSP during the fever. In addition to 45-minute retention, BSP clearances, the values for the parameters of a compartmental model of BSP metabolism, and relative hepatic BSP storage capacity were calculated by computer from the experimental curves. Although only 9 of the 20 fever volunteers had abnormal BSP retention at 45 minutes, all pyrogen-treated subjects had significant changes in values for the compartmental parameters. The largest changes were in the values for BSP reflux from liver to plasma, which increased to 587% of control values, and for relative hepatic BSP storage capacity, which fell by 46%. These results indicate that caution must be used in interpreting the BSP test in patients who are even mildly febrile.
Article and Author Information
-
▸From the Metabolism Branch, National Cancer Institute, and the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
-
▸Address reprint requests to Dr. Paul D. Berk, National Cancer Institute, National Institutes of Health, Building 10, Room 4N117, Bethesda, Md. 20014.
-
- Received September 8, 1972.
- Accepted November 1, 1972.
Related Clinical Content
