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Hypouricemia in Hodgkin's Disease
- JOEL S. BENNETT, M.D.;
- JAMES BOND, M.D.;
- IRWIN SINGER, M.D., F.A.C.P.; and
- ARLAN J. GOTTLIEB, M.D.
Abstract
Two patients with advanced Hodgkin's disease had persistent hypouricemia. Renal clearance studies showed elevated uric acid clearances of 35 and 23 ml/min, respectively. Only minimal abnormalities of other renal tubular functions were present. In both cases the abnormal renal handling of uric acid was corrected with therapy of the Hodgkin's disease, strongly suggesting that the disease was the causal factor. In one patient Hodgkin's disease and hypouricemia recurred, associated with a renal uric acid clearance of 20 to 25 ml/min, and studies with pyrazinamide were done. Assuming that pyrazinamide nearly completely blocks renal tubular secretion of uric acid in man, the study suggests that excessive secretion of uric acid was the cause of the serum and urine abnormalities.
Article and Author Information
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▸From the Department of Medicine, Section of Hematology and Nephrology, University of Pennsylvania School of Medicine; and Veterans Administration Hospital; Philadelphia, Pa.
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Supported in part by training grant AM05228 from the National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Md., and bequest from the C.W. Robinson Foundation, Philadelphia, Pa. Dr. Singer is an Established Investigator of the American Heart Association, New York, N.Y.; he is supported by grant 1-R01-HE14012-01 from the USPHS, Washington, D.C.
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▸Requests for reprints should be addressed to Arlan J Gottlieb, M.D., Department of Medicine, SUNY, Upstate Medical Center, 750 E. Adams St., Syracuse, N.Y. 13210.
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- Received November 1, 1971.
- Accepted January 31, 1972.
