Signorina Galieri's Scleroderma or Scleredema

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To the editor: Dr. Benedek and I have shared Dr. Capusan's doubts concerning the nature of the illness of the young woman described by Dr. Curzio in 1753 (1) and in a recent chapter on progressive systemic sclerosis. I, too, have suggested that signorina Patrizia Galieri may have had scleredema adultorum of Buschke rather than scleroderma (2). I would take issue, however, with several of the arguments adduced by Dr. Capusan in excluding the diagnosis of scleroderma. Particularly, I do not believe that the absence of Raynaud's phenomenon (point 2) can be regarded as crucial, since a small but significant