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Primary Hyperoxaluria with Normal Alpha-Ketoglutarate:Glyoxylate Carboligase Activity
Treatment with Isocarboxazid
- E. BOURKE, M.D.;
- G. FRINDT, M.D.;
- PAULINE FLYNN, B.A.; and
- G. E. SCHREINER, M.D., F.A.C.P.
Abstract
A 10-year-old girl with primary hyperoxaluria, calcium oxalate nephrolithiasis, and normal blood urea was studied. Despite high urinary oxalate and glycolate excretion, normal activity of α-ketoglutarate:glyoxylate carboligase was observed in both mitochondria-containing and soluble cytoplasmic fractions of striated muscle tissue. No effect on the urinary excretion of oxalate or glycolate was observed with the administration of pyridoxine, allopurinol, or calcium carbimide. A 40% reduction in urinary oxalate excretion was produced by isocarboxazid therapy. Further studies are necessary to elucidate the role of monoamine oxidase inhibitors in the treatment of primary hyperoxaluria.
Article and Author Information
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▸From the Nephrology Division, Department of Medicine, Georgetown University School of Medicine, Washington, D.C.
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Part of this work was conducted through the Georgetown University Clinical Study Unit, supported by grant FR-60, National Institutes of Health, Bethesda, Md. Supported in part by the John A. Hartford Foundation, Inc., New York, N.Y. Dr. Frindt was a Fellow of the W. K. Kellogg Foundation, Battle Creek, Mich. Dr. Bourke was a Merck Sharp and Dohme International Fellow in Clinical Pharmacology, West Point, Pa.
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▸Requests for reprints should be addressed to Edmund Bourke, M.D., Department of Medicine, Meath Hospital, Dublin, Ireland.
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- Received July 15, 1971.
- Accepted September 16, 1971.
