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Goodpasture's Syndrome Associated with Influenza A2 Virus Infection
- CURTIS B. WILSON, M.D., F.A.C.P.; and
- ROBERT C. SMITH, M.D.
Abstract
A woman developed severe hemoptysis and glomerulonephritis (Goodpasture's syndrome) in association with an apparent influenza A2 virus infection. The proliferative glomerular lesion contained immunofluorescent deposits of immunoglobulin and complement in a linear pattern along the glomerular basement membrane (GBM), suggesting the presence of anti-GBM antibodies. The pulmonary and renal functional abnormalities rapidly diminished and were absent on examination 5 years after the original illness. This suggested that the response was short-lived and may have been triggered by a transient, virally associated antigenic stimulus.
Article and Author Information
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▸From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif., and the Department of Medicine, University of Iowa, Iowa City, Iowa.
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Supported in part by contract PH-43-68-621, U.S. Public Health Service, Washington, D.C.
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▸Requests for reprints should be addressed to Curtis B. Wilson, M.D., Scripps Clinic and Research Foundation, 476 Prospect St., La Jolla, Calif. 92037
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- Received June 28, 1971.
- Accepted October 1, 1971.
