RSS Feeds
Chloramphenicol-Induced Hemolysis in Caucasian Glucose-6-Phosphate Dehydrogenase Deficiency
- Lt. RONALD P. MCCAFFREY;
- CHARLES H. HALSTED, M.D.;
- MOHAMMED FATHY ABDEL WAHAB, M.B., Ch.B., DTM & H., D.M.; and
- Lt. R. PAUL ROBERTSON
Abstract
Three white G6PD-deficient patients suffered severe hemolytic reactions during treatment for typhoid fever with chloramphenicol. Two of these patients were studied when free of infection to determine the hemolytic potential of chloramphenicol in the noninfected G6PD-deficient white person. It was found to be mildly hemolytic under these conditions, suggesting that a drug-disease synergism was primarily responsible for the clinical hemolytic reactions. The febrile state itself, or changes in plasma amino acids accompanying infection, may be responsible for disease-related hemolysis.
Article and Author Information
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▸From U.S. Naval Medical Research Unit No. 3, and the Government Fever Hospital, Abbasiah, Cairo, U.A.R.
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The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the U.S. Navy Department.
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▸Requests for reprints should be addressed to Ronald P. McCaffrey, M.D., Department of Hematology, Peter Bent Brigham Hospital, Boston, Mass. 02115
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- Received March 10, 1970.
- Accepted January 29, 1971.
