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Graves' Disease with Delayed Hyperthyroidism
Onset After Several Years of Euthyroid Ophthalmopathy, Dermopathy, and High Serum LATS
Abstract
A patient had high serum long-acting thyroid stimulator (LATS) activity and only the ophthalmopathy and dermopathy of Graves' disease for several years and finally developed hyperthyroidism with no increase (actually a decrease) in serum LATS activity. This sequence generates doubt about two prevalent hypotheses: that circulating LATS is the cause of hyperthyroidism in Graves' disease and that the absence of hyperthyroidism in euthyroid Graves' disease is caused by the presence of an additional lesion, such as chronic thyroiditis, limiting the capacity of the thyroid gland to respond to LATS. Alternative hypotheses are discussed.
Article and Author Information
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▸From the Department of Medicine, Harbor General Hospital, Torrance, Calif.; and UCLA School of Medicine, Los Angeles, Calif.
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Supported in part by grant RR00425, Clinical Research Center, Harbor General Hospital, Torrance, Calif.; grant AM10187, U.S. Public Health Service, Washington D.C.; and by a grant from the John A. Hartford Foundation, Inc., New York, N.Y.
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▸Requests for reprints should be addressed David H. Solomon, M.D., Dept. of Medicine, Harbor General Hospital, 1000 W. Carson St., Torrance, Calif. 90509
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- Received June 15, 1970.
- Accepted August 18, 1970.
