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Persistent Salmonella Infection in a Female Carrier for Chronic Granulomatous Disease
Abstract
A female carrier for chronic granulomatous disease of childhood has had persistent systemic infections with Salmonella enteritidis for more than 3 years despite rigorous medical and surgical attempts to eradicate the sepsis. Unusual susceptibility to bacterial infection has not previously been described in carriers of chronic granulomatous disease of childhood, and it is postulated that this patient's persistent infection is due to survival of salmonellae in the macrophages of her reticuloendothelial system, where they are protected from the effects of systemic antibiotics.
Article and Author Information
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▸From the Department of Medicine, Harvard Medical School, and the Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital, Boston, Mass.
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Dr. Moellering was supported by a fellowship from the Medical Foundation of Boston.
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▸Requests for reprints should be addressed to Robert C. Moellering, Jr., M.D., Infectious Disease Unit, Massachusetts General Hospital, Boston, Mass. 02114
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- Received May 1, 1970.
- Accepted July 2, 1970.
