RSS Feeds
Immunologic Abnormalities Induced by Postperfusion Cytomegalovirus Infection
- GARY L. KANTOR, M.D.;
- LEONARD S. GOLDBERG, M.D.;
- B. LAMAR JOHNSON, JR., M.D.;
- MICHAEL M. DERECHIN, M.D.; and
- EUGENE V. BARNETT, M.D., F.A.C.P.
Abstract
Clinical and immunologic features in ten patients with cytomegalovirus-induced postperfusion syndrome were studied. Fever, hepatosplenomegaly, and lymphocytosis were the most frequent clinical manifestations. In addition, lymphocytic leukemoid reactions were present in two patients, glomerulitis in one, and transient anemia in five. In three anemic subjects erythrocyte autoantibodies were found. Immunologic aberrations including rheumatoid factor, antinuclear antibodies, cold agglutinins, and cryoglobulins were detected in 9 of the 10 patients. The immunologic abnormalities appeared during the cytomegalovirus infection, disappeared when the mononucleosis-like syndrome resolved, and were not present in a control group consisting of 29 patients who had undergone cardiopulmonary bypass without developing cytomegalovirus infection. These observations indicate that cytomegalovirus infection can induce a variety of clinical and immunologic abnormalities in postperfusion patients.
Article and Author Information
-
▸From the Nephrology Section, Wadsworth General Hospital, Veterans Administration Center; and the Department of Medicine, University of California School of Medicine; Los Angeles, Calif.
-
Supported in part by the Louis B. Mayer Foundation for Medical Education and Research, and grants GM-15759 and AM-11170, U. S. Public Health Services, Washington, D.C.
-
▸Requests for reprints should be addressed to Gary L. Kantor, M.D., Department of Experimental Pathology, Scripps Clinic & Research Foundation, 476 Prospect St., La Jolla, Calif. 92037
-
- Received May 4, 1970.
- Accepted June 26, 1970.
Related Clinical Content
