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The XYY Chromosomal Complement and Nodulocystic Acne
- JOHN J. VOORHEES, M.D.;
- EMMET HAYES, M.D.;
- JAMES WILKINS, M.D.; and
- RICHARD E. HARRELL, M.D.
Abstract
Previous investigators have noted scarring acne in several patients with the XYY chromosomal complement. This prompted our cytogenetic anlysis of an 18-year-old man whose nodulocystic acne apparently began at age 3. Morphologic studies and tritiated thymidine labeling of chromosomes prepared from his peripheral blood and skin cells showed an XYY sex-chromosome constitution. The unusually early onset of cystic lesions suggests that acne and the XYY genotype in this patient might be more than coincidental. Further study of the possible value of nodulocystic acne as a clinical marker of persons with an increased XYY risk is warranted. A comparison of XX, XY, and XYY subjects with and without cystic acne might show variations in Y-regulated gene products important to the pathobiology of acne.
Article and Author Information
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▸From the Department of Dermatology, The University of Michigan Medical School, Ann Arbor, Mich.
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Dr. Voorhees was supported by the Carl Herzog Fellowship of the American Dermatological Association.
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▸Requests for reprints should be addressed to John J. Voorhees, M.D., Department of Dermatology, Kresge Medical Research Building, University of Michigan Medical Center, Ann Arbor, Mich. 48104
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- Received March 6, 1970.
- Accepted April 30, 1970.
