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Massive Unilateral Pulmonary Fibrosis
Clinical, Physiologic, and Morphologic Studies
- ARTHUR A. COHEN, M.D.;
- PAUL M. STEVENS, M.D., F.A.C.P.;
- S. DONALD GREENBERG, M.D.; and
- GERALD M. LEMOLE, M.D.
Abstract
A patient with massive unilateral pulmonary fibrosis showed pathological evidence of dense organized fibrous tissue with patent pulmonary arteries and veins traversing the areas of dense fibrosis. A few of the bronchioles were occluded with organized fibrous tissue, although most were patent. Preoperative physiologic evaluation showed hypoxemia and pulmonary hypertension. Pulmonary angiograms demonstrated decreased but definite perfusion of the fibrotic lung which was undetected by radioisotopic techniques. Resection of the fibrotic lung was associated with a significant improvement in arterial oxygen tension and a lowering of the pulmonary artery pressure.
Article and Author Information
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▸From the Departments of Medicine and Pathology, Baylor College of Medicine; and the Pulmonary Physiology Laboratory, Methodist Hospital; Houston, Tex.
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Dr. Cohen was supported in part by grant G03-RM-000O7, U. S. Public Health Service, Washington, D.C.
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▸Requests for reprints should be addressed to Arthur A. Cohen, M.D., Pulmonary Physiology Laboratory, Methodist Hospital, Houston, Tex. 77025
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- Received October 13, 1969.
- Accepted November 20, 1969.
