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PROPOXYPHENE TOXICITY
- JOEL S. KARLINER, M.D.
Excerpt
To the Editor: There is a factual error in the otherwise excellent report of Wolfe, Reidenberg, and Vispo on propoxyphene (Darvon®) addiction and withdrawal, (Ann. Intern. Med. 70: 773, 1969). In the discussion section of their paper the authors state that only a ". . . single reported fatality . . ." has resulted from propoxyphene (Darvon®) overdose. There are at least three other well-documented fatal cases in the literature (1-3) and mention of a fourth (4), aside from the report cited by the authors (5).
In one case the fatal ingestion of 2,300 mg of propoxyphene (2), an amount
