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The Marfanoid Hypermobility Syndrome
- BRYAN A. WALKER, M.B., M.R.C.P.;
- PETER H. BEIGHTON, M.D.; and
- J. LAMONT MURDOCH, M.D.
- Requests for reprints should be addressed to J. L. Murdoch, Loma Linda University Hospital, Loma Linda, Calif. 92354
SUMMARY
A patient had the marfanoid habitus but no evidence of evolvement of the aorta or dislocation of the lenses. This was associated with extreme, generalized hypermobility of the joints and marked hyperextensibility of the skin, suggesting the Ehlers-Danlos syndrome. There have been at least four previous reports of this combination of findings. The clinical features of this condition differ significantly from those of both the Marfan syndrome and the Ehlers-Danlos syndrome, and it is suggested that this marfanoid hypermobility syndrome is a distinct entity within the heritable disorders of connective tissue.
Article and Author Information
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From the Division of Medical Genetics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md. 21205.
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Dr. Walker was supported in this study by grant 39486, Bureau of State Services, U. S. Public Health Service, Washington, D. C.; Dr. Beighton was supported by grant CRCS.48, National Foundation—March of Dimes, New York, N. Y.; and Dr. Murdoch was supported by training grant GM 00795, U. S. Public Health Service.
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- Received February 12, 1969.
- Accepted March 14, 1969.
