Pemphigus Vulgaris Successfully Treated with Cyclophosphamide
- ALAN EBRINGER, M.B., M.R.A.C.P.; and
- IAN R. MACKAY, M.D., F.R.C.P., F.R.A.C.P.
- Requests for reprints should be addressed to Dr. Ian Mackay, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.
SUMMARY
A 49-year-old woman had pemphigus vulgaris for 8 years. She had been treated for 5 years with prednisolone in increasingly high doses, up to 200 mg daily, and had developed numerous and life-threatening side-effects. She was treated over the last 3 years with cyclophosphamide, 200 mg daily, in four separate courses. This allowed gradual reduction in the high maintenance doses of prednisolone and induced remissions.
Article and Author Information
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From the Clinical Research Unit of The Walter and Eliza Hall Institute of Medical Research and The Royal Melbourne Hospital, Victoria, Australia.
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Dr. Mackay was aided in this study by a grant from the National Health and Medical Research Council of Australia, Canberra, Australia.
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- Received December 19, 1968.
- Accepted February 21, 1969.
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