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Clinical Epidemiology
III. The Clinical Design of Statistics in Therapy
- ALVAN R. FEINSTEIN, M.D., F.A.C.P.
- Requests for reprints should be addressed to Alvan R. Feinstein, M.D., Yale University School of Medicine, 333 Cedar St., New Haven, Conn. 06510
Excerpt
OUTLINE OF CONTENTS: PART III INTRODUCTION
PROGNOSTIC DISTINCTIONS
INDEX OF ACCOMPLISHMENT
CORRELATED PROGNOSTIC STRATIFICATION
THE ASSESSMENT OF CO-MORBIDITY
POPULATIONAL TRANSFERS
INVESTIGATOR'S CHOICE OF TEMPORAL DEMARCATIONS
DECISIONS MADE BY PATIENTS AND DOCTORS
TAXONOMIC LOGISTICS
NONCLINICAL PRINCIPLES
"CONTROL" TREATMENT
DOUBLE-BLIND TECHNIQUE
RANDOM ALLOCATION
SUMMARY
INTRODUCTION Perhaps the most striking intellectual change in modern treatment has been its frequent conversion from an act of clinical medicine to an act of statistics.
Reports that lack appropriate statistical analysis will regularly be rejected today by the editors of leading medical journals; various papers in contemporary medical literature recurrently provide instructive discussions of statistical principles useful
Article and Author Information
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From the Eastern Research Support Center and the Department of Medicine, West Haven Veterans Administration Hospital, West Haven; and the Departments of Medicine and Epidemiology, Yale University School of Medicine, New Haven; Conn.
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This study was supported in part by grant 13977-03-68-06, Department of Health, Education, and Welfare, U. S. Public Health Service Cancer Control Program, Washington, D. C.
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- Received October 30, 1967.
- Accepted May 31, 1968.
