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Ethanol Gelation: A Rapid Screening Test for Intravascular Coagulation
- FRANCIS A. BREEN, JR., M.D.; and
- JAMES L. TULLIS, M.D.
- Requests for reprints should be addressed to James L. Tullis, M.D., Cytology Laboratory, Blood Research Institute, Inc., Suite 6-A, 110 Francis St., Boston, Mass. 02215.
SUMMARY
The ability of ethanol to gel soluble fibrin (fibrin monomer) in an in vitro test system and its further applicability in clinical situations are reported. Five patients with clinically documented disseminated intravascular coagulation had positive ethanol gelation tests. Thirty-six others, including four with hypofibrinogenemia from primary fibrinolysis, were negative. The ethanol test described is a simple, rapid screening procedure to distinguish between hypofibrinogenemia due to disseminated intravascular coagulation and hypofibrinogenemia due to primary fibrinolysis.
Article and Author Information
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From the Department of Medicine, New England Deaconess Hospital; and the Cytology Laboratory, Blood Research Institute, Inc.; Boston, Mass.
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This study was supported in part by grants HE 063-2-06 and HE 08250-03, National Institutes of Health, Bethesda, Md.; and by grant 1-F2-HE 32-116-01, U. S. Public Health Service, Washington, D. C.
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- Received May 10, 1968.
- Accepted July 16, 1968.
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