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Aldosterone Secretion in Hypertension
- JACK M. GEORGE, M.D.;
- LOUIS GILLESPIE, M.D., F.A.C.P.; and
- FREDERIC C. BARTTER, M.D.
- Requests for reprints should be addressed to Frederic C. Bartter, M.D., Bldg. 10, Rm. 8N214, National Institutes of Health, Bethesda, Md. 20014.
SUMMARY
The rate of secretion and excretion of aldosterone was measured in 44 hypertensive patients. The method used for determining aldosterone secretion rate appeared to give valid results even in patients with renal failure.
Hyperaldosteronism was uncommon in "benign" hypertension; its presence should suggest the possibility of curable hypertension resulting from adrenal cortical adenoma, bilateral adrenal cortical hyperplasia, or renal artery disease. However, hyperaldosteronism was also uncommon in patients with renal artery disease. In three patients previously untreated with antihypertensive medication, hyperaldosteronism disappeared after blood pressure was controlled.
Article and Author Information
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From the Clinical Endocrinology and Experimental Therapeutics Branches, National Heart Institute, National Institutes of Health, Bethesda, Md. 20014.
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- Received August 24, 1967.
- Accepted June 24, 1968.
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