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The Significance of Nontoxic Thyroid Nodules
Final Report of a 15-Year Study of the Incidence of Thyroid Malignancy
- JOHN B. VANDER, M.D., F.A.C.P.;
- EUGENE A. GASTON, M.D.; and
- THOMAS R. DAWBER, M.D., F.A.C.P.
- Requests for reprints should be addressed to John B. Vander, M.D., Prudential Life Insurance Co., 800 Boyleston Ave., Boston, Mass. 02119.
SUMMARY
In a total population of 5,127 persons, 218 were found to have nontoxic thyroid nodules, representing 4.2% of the sample—6.4% in females and 1.5% in males.
These lesions were followed for a period of approximately 15 years, and none showed evidence of malignancy at the end of that time.
During the 15-year period of observation, 67 new lesions were detected in persons previously found to be free of thyroid disease. This represented a 15-year incidence rate of 1.4%, 1.7% in females and 0.9% in males. None of these newly detected lesions showed evidence of malignancy.
Article and Author Information
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From the Heart Disease Epidemiology Study, Framingham, Mass.; and the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.
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- Received April 15, 1968.
- Accepted May 9, 1968.
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