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Agranulocytosis with Monohistiocytosis Associated with Ampicillin Therapy
- MARTIN GRAF, M.D.; and
- ALVIN TARLOV, M.D.
- Requests for reprints should be addressed to Martin W. Graf., M.D., Irvington House Research Institute, New York University Medical School, 550 First Ave., New York, N. Y. 10016.
SUMMARY
A case is presented of a patient who developed agranulocytosis with a peripheral monocytosis and a marrow histiocytosis secondary to ampicillin therapy. A brief review of this complex, previously called leukopenic infectious monocytosis, is presented, with emphasis upon the beneficial prognosis of monocytosis. Since this is the first case report of agranulocytosis induced by ampicillin, ampicillin's chemical structure is examined. It is pointed out that ampicillin contains an alpha-aminobenzene, a structure common to many drugs previously implicated in causing agranulocytosis. A brief discussion of the previously postulated causal mechanisms involved in agranulocytosis is presented.
Article and Author Information
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From the Department of Medicine, University of Chicago Hospitals and Clinics, and the Argonne Cancer Research Hospital, Chicago, Ill.
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This work was supported by the Argonne Cancer Research Hospital, Chicago, Ill.
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Dr. Tarlov was supported by a Scholarship in Academic Medicine, John and Mary R. Markle Foundation, New York, N. Y., and U. S. Public Health Service Research Career Development Award K3-Am-7706, Washington, D. C.
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- Received December 26, 1967.
- Accepted March 26, 1968.
