Microangiopathic Hemolytic Anemia Caused by Purpura Fulminans

  1. JOHN H. HOLLINGSWORTH, M.D.; and
  2. DANIEL N. MOHLER, M.D., F.A.C.P.
  1. Requests for reprints should be addressed to Daniel N. Mohler, M.D., Department of Internal Medicine, University of Virginia Hospital,
    Charlottesville, Va. 22901
    .

SUMMARY

A patient with rapidly advancing ecchymoses, gangrene of the skin, hemolytic anemia, and intravascular coagulation after reduction of a rectal prolapse is presented. The hematologic abnormalities returned to normal after large doses of corticosteroids were used, but extensive cutaneous gangrene proved fatal. Pathologic examination revealed no evidence of hyaline thrombi suggestive of thrombotic thrombocytopenic purpura, and the patient was thought to represent an unusually extensive case of purpura fulminans associated with microangiopathic hemolytic anemia.

Article and Author Information

  • From the Department of Medicine, University of Virginia School of Medicine, and the University of Virginia Hospital, Charlottesville, Va.

    • Received December 26, 1967.
    • Accepted February 12, 1968.
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