RSS Feeds
Steroid Resistance in Bronchial Asthma.
- Howard J. Schwartz, M.D.;
- Francis C. Lowell, M.D., F.A.C.P.; and
- James C. Melby, M.D.
Excerpt
Relative resistance to corticosteroid therapy was observed in some asthmatic patients. The eosinopenic responses to 40 mg cortisol intravenously in 19 unselected asthmatics (group A) and 6 resistant asthmatics (group B) were measured by following changes in total eosinophil counts (TEC). The percent TEC changes were -35, -77, and -73 in group A and -10, -36, and +5 in group B at 2, 4, and 6 hr after administration. These differences were highly significant (P = 0.01) and independent of the base-line TEC.
Cortisol turnover studies in four subjects from each group were done. Each patient received a tracer dose
This 100-word excerpt has been provided in the absence of an abstract.
