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Pseudoleukemia During Recovery from Dapsone-Induced Agranulocytosis
- PETER H. LEVINE, M.D.; and
- LEWIS R. WEINTRAUB, M.D., F.A.C.P.
- Requests for reprints should be addressed to Peter H. Levine, M.D., Blood Research Laboratory, New England Medical Center Hospitals, 171 Harrison Ave., Boston, Mass. 02111.
SUMMARY
The case presented here illustrates how convincingly the recovery from agranulocytosis may mimic acute leukemia in both the peripheral blood and the bone marrow. The development of a leukemia-like syndrome in any patient who has been exposed to a drug known to cause agranulocytosis should raise the question of "pseudoleukemia." Repeated bone marrow aspirations and daily observation of changes in peripheral blood parameters will help prevent needless exposure to myelosuppressive agents. The experience with this case makes mandatory an awareness of agranulocytosis as a side effect of dapsone.
Article and Author Information
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From the Blood Research Laboratory, New England Medical Center Hospitals, and the Department of Medicine, Tufts University School of Medicine, Boston, Mass.
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Dr. Levine was supported in this study by trainee grant TI-AM-5210-08, U. S. Public Health Service, Washington, D. C. Dr. Weintraub was recipient of career award PHS-AM-31243-01, U. S. Public Health Service.
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- Received December 18, 1967.
- Accepted January 25, 1968.
