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The Application of Multicompartmental Analysis to Problems of Clinical Medicine
Combined Clinical Staff Conference at the National Institutes of Health
- NATHANIEL I. BERLIN, M.D.;
- MONES BERMAN, PH.D.;
- PAUL D. BERK, M.D.;
- JAMES M. PHANG, M.D.; and
- THOMAS A. WALDMANN, M.D.
- Requests for reprints should be addressed to Nathaniel I. Berlin, M.D., Clinical Director, National Cancer Institute, Bldg. 10, Room 4-B-17, National Institutes of Health, Bethesda, Md. 20014.
SUMMARY
This combined Clinical Staff Conference presents the mathematical basis and the investigational techniques and tools of compartmental analysis in the study of calcium, bilirubin, and immunoglobulin metabolism, with examples of studies in disease states and discussion of limitations.
The dynamics of bilirubin metabolism are illustrated with data from normals and from patients with Gilbert's disease, Dubin-Johnson syndrome, and cirrhosis.
Calcium metabolism and its hormonal regulation are discussed in the light of studies in normals and hypoparathyroid patients. Data from normals and patients with disorders of immunoglobulin catabolism (myotonic dystrophy, ataxia telangiectasia, etc.), loss (for example, intestinal lymphangiectasia), and decreased immunoglobulin synthesis illustrate analysis of immunoglobulin metabolism.
Article and Author Information
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This is an edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda, Md., by the National Cancer Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.
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- Received November 20, 1967.
- Accepted December 7, 1967.
